Publications by Current and Former Trainees

  • Kim DS, Gloyn AL, Knowles JW. Genetics of Type 2 Diabetes: Opportunities for Precision Medicine: JACC Focus Seminar. J Am Coll Cardiol. 2021 Aug 3;78(5):496-512. doi: 10.1016/j.jacc.2021.03.346. PMID: 34325839; PMCID: PMC8328195.
  • Kim DS, Risca VI, Reynolds DL, Chappell J, Rubin AJ, Jung N, Donohue LKH, Lopez-Pajares V, Kathiria A, Shi M, Zhao Z, Deep H, Sharmin M, Rao D, Lin S, Chang HY, Snyder MP, Greenleaf WJ, Kundaje A, Khavari PA. The dynamic, combinatorial cis-regulatory lexicon of epidermal differentiation. Nat Genet. 2021 Nov;53(11):1564-1576. doi: 10.1038/s41588-021-00947-3. Epub 2021 Oct 14. PMID: 34650237; PMCID: PMC8763320.
  • Kim DS, Wheeler MT, Ashley EA. The genetics of human performance. Nat Rev Genet. 2022 Jan;23(1):40-54. doi: 10.1038/s41576-021-00400-5. Epub 2021 Sep 14. PMID: 34522035.
  • Gomez SE, Hwang CE, Kim DS, Froelicher VF, Wheeler MT, Perez MV. Premature ventricular contractions (PVCs) in young athletes. Prog Cardiovasc Dis. 2022 ;74:80-88. doi: 10.1016/j.pcad.2022.10.011. Epub 2022 Oct 26. PMID: 36309100.
  • Reggiardo RE, Maroli SV, Kim DH. LncRNA Biomarkers of Inflammation and Cancer. Adv Exp Med Biol. 2022;1363:121-145. doi: 10.1007/978-3-030-92034-0_7. PMID: 35220568.
  • Kim DS, Khandelwal A. Lipoprotein(a) and Incident Atrial Fibrillation: Leveraging Nature's Randomization to Identify Novel Causal Associations. J Am Coll Cardiol. 2022 Apr 26;79(16):1591-1593. doi: 10.1016/j.jacc.2022.02.026. PMID: 35450576.
  • Reggiardo RE, Maroli SV, Halasz H, Ozen M, Hrabeta-Robinson E, Behera A, Peddu V, Carrillo D, LaMontagne E, Whitehead L, Malik S, Fernandes J, Marinov G, Collisson E, Brooks A, Demirci U, Kim DH. Mutant KRAS regulates transposable element RNA and innate immunity via KRAB zinc-finger genes. Cell Rep. 2022 Jul 19;40(3):111104. doi: 10.1016/j.celrep.2022.111104. PMID: 35858545; PMCID: PMC9374308.
  • Donohue LKH, Guo MG, Zhao Y, Jung N, Bussat RT, Kim DS, Neela PH, Kellman LN, Garcia OS, Meyers RM, Altman RB, Khavari PA. A -regulatory lexicon of DNA motif combinations mediating cell-type-specific gene regulation. Cell Genom. 2022 Nov 9;2(11):10.1016/j.xgen.2022.100191. doi: 10.1016/j.xgen.2022.100191. Epub 2022 Oct 5. PMID: 36742369; PMCID: PMC9894309.
  • Kim DS. ATAC-seq Data Processing. Methods Mol Biol. 2023;2611:305-323. doi: 10.1007/978-1-0716-2899-7_17. PMID: 36807076.
  • Kim DS. Deep Learning on Chromatin Accessibility. Methods Mol Biol. 2023;2611:325-333. doi: 10.1007/978-1-0716-2899-7_18. PMID: 36807077.
  • Kim DS, Wiel L, Ashley EA. Mind the Gap: The Complete Human Genome Unlocks Benefits for Clinical Genomics. Clin Chem. 2023 Jan 4;69(1):6-8. doi: 10.1093/clinchem/hvac133. PMID: 36112529.
  • Carrillo D, Reggiardo RE, Lim J, Mantalas G, Peddu V, Kim DH. Transposable element RNA dysregulation in mutant KRAS(G12C) 3D lung cancer spheroids. bioRxiv. 2023 Feb 28:10.1101/2023.02.27.530369. doi: 10.1101/2023.02.27.530369. PMID: 36909578; PMCID: PMC10002638.
  • Hitz BC, Jin-Wook L, Jolanki O, Kagda MS, Graham K, Sud P, Gabdank I, Strattan JS, Sloan CA, Dreszer T, Rowe LD, Podduturi NR, Malladi VS, Chan ET, Davidson JM, Ho M, Miyasato S, Simison M, Tanaka F, Luo Y, Whaling I, Hong EL, Lee BT, Sandstrom R, Rynes E, Nelson J, Nishida A, Ingersoll A, Buckley M,... Kim DS, et al. The ENCODE Uniform Analysis Pipelines. bioRxiv. 2023 Apr 6:10.1101/2023.04.04.535623. doi: 10.1101/2023.04.04.535623. PMID: 37066421; PMCID: PMC10104020.
  • Velleca A, Shullo MA, Dhital K, Azeka E, Colvin M, DePasquale E, Farrero M, Garcia-Guereta L, Jamero G, Khush K, Lavee J, Pouch S, Patel J, Michaud CJ, Shullo MA, Schubert S, Angelini A, Carlos L, Mirabet S, Patel J, Pham M, Urschel S, Miyamoto S, Chih S, Daly K, Grossi P, Jennings DL, Lim HS, Miller T,... Kim D, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2023 May;42(5):e1-e141. doi: 10.1016/j.healun.2022.10.015. Epub 2022 Dec 20. PMID: 37080658.
  • Han J, Moayedi Y, Henricksen EJ, Waddell K, Valverde-Twiggs J, Kim D, Luikart H, Zhang BM, Teuteberg J, Khush KK. Primary Graft Dysfunction Is Associated With Development of Early Cardiac Allograft Vasculopathy, but Not Other Immune-mediated Complications, After Heart Transplantation. Transplantation. 2023 Jul 1;107(7):1624-1629. doi: 10.1097/TP.0000000000004551. Epub 2023 Jun 20. PMID: 36801852.
  • Hitz BC, Lee JW, Jolanki O, Kagda MS, Graham K, Sud P, Gabdank I, Strattan JS, Sloan CA, Dreszer T, Rowe LD, Podduturi NR, Malladi VS, Chan ET, Davidson JM, Ho M, Miyasato S, Simison M, Tanaka F, Luo Y, Whaling I, Hong EL, Lee BT, Sandstrom R, Rynes E, Nelson J, Nishida A, Ingersoll A, Buckley M,... Kim DS, et al. The ENCODE Uniform Analysis Pipelines. Res Sq. 2023 Jul 19:10.21203/rs.3.rs-3111932/v1. doi: 10.21203/rs.3.rs-3111932/v1. PMID: 37503119; PMCID: PMC10371165.
  • Javed A, Kim DS, Hershman SG, Shcherbina A, Johnson A, Tolas A, O'Sullivan JW, McConnell MV, Lazzeroni L, King AC, Christle JW, Oppezzo M, Mattsson CM, Harrington RA, Wheeler MT, Ashley EA. Personalized digital behaviour interventions increase short-term physical activity: a randomized control crossover trial substudy of the MyHeart Counts Cardiovascular Health Study. Eur Heart J Digit Health. 2023 Aug 9;4(5):411-419. doi: 10.1093/ehjdh/ztad047. PMID: 37794870; PMCID: PMC10545510.
  • Thrane K, Winge MCG, Wang H, Chen L, Guo MG, Andersson A, Abalo XM, Yang X, Kim DS, Longo SK, Soong BY, Meyers JM, Reynolds DL, McGeever A, Demircioglu D, Hasson D, Mirzazadeh R, Rubin AJ, Bae GH, Karkanias J, Rieger K, Lundeberg J, Ji AL. Single-Cell and Spatial Transcriptomic Analysis of Human Skin Delineates Intercellular Communication and Pathogenic Cells. J Invest Dermatol. 2023 Nov;143(11):2177-2192.e13. doi: 10.1016/j.jid.2023.02.040. Epub 2023 May 2. PMID: 37142187; PMCID: PMC10592679.
  • Reggiardo RE, Maroli SV, Peddu V, Davidson AE, Hill A, LaMontagne E, Aaraj YA, Jain M, Chan SY, Kim DH. Profiling of repetitive RNA sequences in the blood plasma of patients with cancer. Nat Biomed Eng. 2023 Dec;7(12):1627-1635. doi: 10.1038/s41551-023-01081-7. Epub 2023 Aug 31. PMID: 37652985; PMCID: PMC10727983.
  • Kim D, Collins JD, White JA, Hanneman K, Lee DC, Patel AR, Hu P, Litt H, Weinsaft JW, Davids R, Mukai K, Ng MY, Luetkens JA, Roguin A, Rochitte CE, Woodard PK, Manisty C, Zareba KM, Mont L, Bogun F, Ennis DB, Nazarian S, Webster G, Stojanovska J. SCMR expert consensus statement for cardiovascular magnetic resonance of patients with a cardiac implantable electronic device. J Cardiovasc Magn Reson. 2024 Jan 12;26(1):100995. doi: 10.1016/j.jocmr.2024.100995. Epub ahead of print. PMID: 38219955.
  • Kim DY, Swetter SM, Huhmann L, Dizon MP, Ferguson JM, Osborne TF, Spence AC, Ziad A, Fillmore N, Hartman RI. Real-world effectiveness of immune checkpoint inhibitors and BRAF/MEK inhibitors among veteran patients with cutaneous melanoma. J Am Acad Dermatol. 2024 Mar;90(3):620-623. doi: 10.1016/j.jaad.2023.10.051. Epub 2023 Nov 3. PMID: 37924953.
  • Wang D, Tediashvili G, Kim D, Hu X, Luikart H, Renne T, Tian A, Nadeau KC, Velden J, Schrepfer S, Khush KK. Leukotriene B4: A potential mediator and biomarker for cardiac allograft vasculopathy. J Heart Lung Transplant. 2024 Apr 24:10.1016/j.healun.2024.04.004. doi: 10.1016/j.healun.2024.04.004. Epub ahead of print. PMID: 38670297.
  • Shiau C, Kim DY, Young PA, Baker A, Bae GH. Trends in dermatologic procedures performed by dermatologists and advanced practice clinicians among Medicare beneficiaries from 2012 to 2020. J Am Acad Dermatol. 2024 May;90(5):1054-1057. doi: 10.1016/j.jaad.2023.12.061. Epub 2024 Jan 17. PMID: 38242175.
  • Cruz RA, Gonzales NA, Corona M, King KM, Cauce AM, Robins RW, Widaman KF, Conger RD. Cultural dynamics and marital relationship quality in Mexican-origin families. J Fam Psychol. 2014 Dec;28(6):844-54. doi: 10.1037/a0038123. Epub 2014 Oct 13. PMID: 25313819; PMCID: PMC4261002.
  • Bertelsen C, King KG, Swanson M, Duddalwar V, Pepper JP. Contrast-Enhanced Ultrasound With Perflubutane for Sentinel Lymph Node Mapping in Cutaneous Melanoma: A Pilot Study. Laryngoscope. 2019 May;129(5):1117-1122. doi: 10.1002/lary.27397. Epub 2018 Oct 3. PMID: 30284307.
  • Tubi MA, Feingold FW, Kothapalli D, Hare ET, King KS, Thompson PM, Braskie MN. White matter hyperintensities and their relationship to cognition: Effects of segmentation algorithm. Neuroimage. 2020 Feb 1;206:116327. doi: 10.1016/j.neuroimage.2019.116327. Epub 2019 Nov 1. PMID: 31682983; PMCID: PMC6981030.
  • Tubi MA, Kothapalli D, Hapenney M, Feingold FW, Mack WJ, King KS, Thompson PM, Braskie MN. Regional relationships between CSF VEGF levels and Alzheimer's disease brain biomarkers and cognition. Neurobiol Aging. 2021 Sep;105:241-251. doi: 10.1016/j.neurobiolaging.2021.04.025. Epub 2021 May 21. PMID: 34126466; PMCID: PMC8544907.
  • Kurtz DM, Gambhir SS. Tracking cellular and immune therapies in cancer. Adv Cancer Res. 2014;124:257-96. doi: 10.1016/B978-0-12-411638-2.00008-2. PMID: 25287692.
  • Cohen JB, Kurtz DM, Staton AD, Flowers CR. Next-generation surveillance strategies for patients with lymphoma. Future Oncol. 2015;11(13):1977-91. doi: 10.2217/fon.15.92. PMID: 26161931; PMCID: PMC4519355.
  • Kurtz DM, Green MR, Bratman SV, Scherer F, Liu CL, Kunder CA, Takahashi K, Glover C, Keane C, Kihira S, Visser B, Callahan J, Kong KA, Faham M, Corbelli KS, Miklos D, Advani RH, Levy R, Hicks RJ, Hertzberg M, Ohgami RS, Gandhi MK, Diehn M, Alizadeh AA. Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing. Blood. 2015 Jun 11;125(24):3679-87. doi: 10.1182/blood-2015-03-635169. Epub 2015 Apr 17. PMID: 25887775; PMCID: PMC4463733.
  • Karmakar S, Harcourt EM, Hewings DS, Scherer F, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET. Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. Nat Chem. 2015 Sep;7(9):752-8. doi: 10.1038/nchem.2307. Epub 2015 Aug 3. PMID: 26291948; PMCID: PMC4545578.
  • Newman AM, Lovejoy AF, Klass DM, Kurtz DM, Chabon JJ, Scherer F, Stehr H, Liu CL, Bratman SV, Say C, Zhou L, Carter JN, West RB, Sledge GW, Shrager JB, Loo BW, Neal JW, Wakelee HA, Diehn M, Alizadeh AA. Integrated digital error suppression for improved detection of circulating tumor DNA. Nat Biotechnol. 2016 May;34(5):547-555. doi: 10.1038/nbt.3520. Epub 2016 Mar 28. PMID: 27018799; PMCID: PMC4907374.
  • Chabon JJ, Simmons AD, Lovejoy AF, Esfahani MS, Newman AM, Haringsma HJ, Kurtz DM, Stehr H, Scherer F, Karlovich CA, Harding TC, Durkin KA, Otterson GA, Purcell WT, Camidge DR, Goldman JW, Sequist LV, Piotrowska Z, Wakelee HA, Neal JW, Alizadeh AA, Diehn M. Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients. Nat Commun. 2016 Jun 10;7:11815. doi: 10.1038/ncomms11815. PMID: 27283993; PMCID: PMC4906406.
  • Scherer F, Kurtz DM, Newman AM, Stehr H, Craig AF, Esfahani MS, Lovejoy AF, Chabon JJ, Klass DM, Liu CL, Zhou L, Glover C, Visser BC, Poultsides GA, Advani RH, Maeda LS, Gupta NK, Levy R, Ohgami RS, Kunder CA, Diehn M, Alizadeh AA. Distinct biological subtypes and patterns of genome evolution in lymphoma revealed by circulating tumor DNA. Sci Transl Med. 2016 Nov 9;8(364):364ra155. doi: 10.1126/scitranslmed.aai8545. PMID: 27831904; PMCID: PMC5490494.
  • Park SM, Wong DJ, Ooi CC, Kurtz DM, Vermesh O, Aalipour A, Suh S, Pian KL, Chabon JJ, Lee SH, Jamali M, Say C, Carter JN, Lee LP, Kuschner WG, Schwartz EJ, Shrager JB, Neal JW, Wakelee HA, Diehn M, Nair VS, Wang SX, Gambhir SS. Molecular profiling of single circulating tumor cells from lung cancer patients. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8379-E8386. doi: 10.1073/pnas.1608461113. Epub 2016 Dec 12. PMID: 27956614; PMCID: PMC5206556.
  • Scherer F, Kurtz DM, Diehn M, Alizadeh AA. High-throughput sequencing for noninvasive disease detection in hematologic malignancies. Blood. 2017 Jul 27;130(4):440-452. doi: 10.1182/blood-2017-03-735639. Epub 2017 Jun 9. PMID: 28600337; PMCID: PMC5881609.
  • Chaudhuri AA, Chabon JJ, Lovejoy AF, Newman AM, Stehr H, Azad TD, Khodadoust MS, Esfahani MS, Liu CL, Zhou L, Scherer F, Kurtz DM, Say C, Carter JN, Merriott DJ, Dudley JC, Binkley MS, Modlin L, Padda SK, Gensheimer MF, West RB, Shrager JB, Neal JW, Wakelee HA, Loo BW, Alizadeh AA, Diehn M. Early Detection of Molecular Residual Disease in Localized Lung Cancer by Circulating Tumor DNA Profiling. Cancer Discov. 2017 Dec;7(12):1394-1403. doi: 10.1158/2159-8290.CD-17-0716. Epub 2017 Sep 24. PMID: 28899864; PMCID: PMC5895851.
  • Kurtz DM, Scherer F, Jin MC, Soo J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Levy R, Newman AM, Duhrsen U, Huttmann A, Meignan M, Casasnovas RO, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Circulating Tumor DNA Measurements As Early Outcome Predictors in Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2018 Oct 1;36(28):2845-2853. doi: 10.1200/JCO.2018.78.5246. Epub 2018 Aug 20. PMID: 30125215; PMCID: PMC6161832.
  • Kurtz DM, Scherer F, Jin MC, Soo J, Craig AFM, Esfahani MS, Chabon JJ, Stehr H, Liu CL, Tibshirani R, Maeda LS, Gupta NK, Khodadoust MS, Advani RH, Newman AM, Duhrsen U, Huttmann A, Meignan M, Casasnovas O, Westin JR, Roschewski M, Wilson WH, Gaidano G, Rossi D, Diehn M, Alizadeh AA. Reply to J. Wang et al. J Clin Oncol. 2019 Mar 20;37(9):755-757. doi: 10.1200/JCO.18.01907. Epub 2019 Feb 12. PMID: 30753108.
  • Kurtz DM, Esfahani MS, Scherer F, Soo J, Jin MC, Liu CL, Newman AM, Duhrsen U, Huttmann A, Casasnovas O, Westin JR, Ritgen M, Bottcher S, Langerak AW, Roschewski M, Wilson WH, Gaidano G, Rossi D, Bahlo J, Hallek M, Tibshirani R, Diehn M, Alizadeh AA. Dynamic Risk Profiling Using Serial Tumor Biomarkers for Personalized Outcome Prediction. Cell. 2019 Jul 25;178(3):699-713.e19. doi: 10.1016/j.cell.2019.06.011. Epub 2019 Jul 4. PMID: 31280963; PMCID: PMC7380118.
  • Kurtz DM. Prognostication with circulating tumor DNA: is it ready for prime time? Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):47-52. doi: 10.1182/hematology.2019000013. PMID: 31808836; PMCID: PMC6913479.
  • Azad TD, Chaudhuri AA, Fang P, Qiao Y, Esfahani MS, Chabon JJ, Hamilton EG, Yang YD, Lovejoy A, Newman AM, Kurtz DM, Jin M, Schroers-Martin J, Stehr H, Liu CL, Hui AB, Patel V, Maru D, Lin SH, Alizadeh AA, Diehn M. Circulating Tumor DNA Analysis for Detection of Minimal Residual Disease After Chemoradiotherapy for Localized Esophageal Cancer. Gastroenterology. 2020 Feb;158(3):494-505.e6. doi: 10.1053/j.gastro.2019.10.039. Epub 2019 Nov 9. PMID: 31711920; PMCID: PMC7010551.
  • Rossi D, Kurtz DM, Roschewski M, Cavalli F, Zucca E, Wilson WH. The development of liquid biopsy for research and clinical practice in lymphomas: Report of the 15-ICML workshop on ctDNA. Hematol Oncol. 2020 Feb;38(1):34-37. doi: 10.1002/hon.2704. Epub 2019 Dec 30. PMID: 31872890.
  • Chabon JJ, Hamilton EG, Kurtz DM, Esfahani MS, Moding EJ, Stehr H, Schroers-Martin J, Nabet BY, Chen B, Chaudhuri AA, Liu CL, Hui AB, Jin MC, Azad TD, Almanza D, Jeon YJ, Nesselbush MC, Co Ting Keh L, Bonilla RF, Yoo CH, Ko RB, Chen EL, Merriott DJ, Massion PP, Mansfield AS, Jen J, Ren HZ, Lin SH, Costantino CL, et al. Integrating genomic features for non-invasive early lung cancer detection. Nature. 2020 Apr;580(7802):245-251. doi: 10.1038/s41586-020-2140-0. Epub 2020 Mar 25. PMID: 32269342; PMCID: PMC8230734.
  • Binkley MS, Jeon YJ, Nesselbush M, Moding EJ, Nabet BY, Almanza D, Kunder C, Stehr H, Yoo CH, Rhee S, Xiang M, Chabon JJ, Hamilton E, Kurtz DM, Gojenola L, Owen SG, Ko RB, Shin JH, Maxim PG, Lui NS, Backhus LM, Berry MF, Shrager JB, Ramchandran KJ, Padda SK, Das M, Neal JW, Wakelee HA, Alizadeh AA, et al. Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition. Cancer Discov. 2020 Dec;10(12):1826-1841. doi: 10.1158/2159-8290.CD-20-0282. Epub 2020 Oct 18. PMID: 33071215; PMCID: PMC7710558.
  • Cirillo M, Craig AFM, Borchmann S, Kurtz DM. Liquid biopsy in lymphoma: Molecular methods and clinical applications. Cancer Treat Rev. 2020 Dec;91:102106. doi: 10.1016/j.ctrv.2020.102106. Epub 2020 Sep 22. PMID: 33049623; PMCID: PMC8043056.
  • Avanzini S, Kurtz DM, Chabon JJ, Moding EJ, Hori SS, Gambhir SS, Alizadeh AA, Diehn M, Reiter JG. A mathematical model of ctDNA shedding predicts tumor detection size. Sci Adv. 2020 Dec 11;6(50):10.1126/sciadv.abc4308. doi: 10.1126/sciadv.abc4308. PMID: 33310847; PMCID: PMC7732186.
  • Kurtz DM. Bringing circulating tumor DNA to the clinic in Hodgkin lymphoma. Haematologica. 2021 Jan 1;106(1):5-6. doi: 10.3324/haematol.2020.265165. PMID: 33386712; PMCID: PMC7776242.
  • Alig S, Macaulay CW, Kurtz DM, Duhrsen U, Huttmann A, Schmitz C, Jin MC, Sworder BJ, Garofalo A, Shahrokh Esfahani M, Nabet BY, Soo J, Scherer F, Craig AFM, Casasnovas O, Westin JR, Gaidano G, Rossi D, Roschewski M, Wilson WH, Meignan M, Diehn M, Alizadeh AA. Short Diagnosis-to-Treatment Interval Is Associated With Higher Circulating Tumor DNA Levels in Diffuse Large B-Cell Lymphoma. J Clin Oncol. 2021 Aug 10;39(23):2605-2616. doi: 10.1200/JCO.20.02573. Epub 2021 Apr 28. PMID: 33909455; PMCID: PMC8331064.
  • Shah AT, Azad TD, Breese MR, Chabon JJ, Hamilton EG, Straessler K, Kurtz DM, Leung SG, Spillinger A, Liu HY, Behroozfard IH, Wittber FM, Hazard FK, Cho SJ, Daldrup-Link HE, Vo KT, Rangaswami A, Pribnow A, Spunt SL, Lacayo NJ, Diehn M, Alizadeh AA, Sweet-Cordero EA. A Comprehensive Circulating Tumor DNA Assay for Detection of Translocation and Copy-Number Changes in Pediatric Sarcomas. Mol Cancer Ther. 2021 Oct;20(10):2016-2025. doi: 10.1158/1535-7163.MCT-20-0987. Epub 2021 Aug 5. PMID: 34353895; PMCID: PMC9307079.